Similar to Sage and Cedar, Palo Santo is most widely used for spiritual purification and energy (house) cleansings. Once the wood sticks are burned, the smoke is believed to clear negative energy and restore tranquility and calm emotions.Inhaling Bursera graveloens smoke results in strong, psychoactive results. Palo Santo is also used as an analgesic, aphrodisiac, diuretic, expectorant and insecticide also has anti-inflammatory effects.